Search on: 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES 
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Descriptor English:   3-Phosphoinositide-Dependent Protein Kinases 
Descriptor Spanish:   Proteína Quinasas Dependientes de 3-Fosfoinositido 
Descriptor Portuguese:   Proteína Quinases Dependentes de 3-Fosfoinositídeo 
Tree Number:   D08.811.913.696.620.682.700.745
Definition English:   Highly conserved protein-serine threonine kinases that phosphorylate and activate a group of AGC protein kinases, especially in response to the production of the SECOND MESSENGERS, phosphatidylinositol 3,4,-biphosphate (PtdIns(3,4)P2) and phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3). 
History Note English:   2014 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   55307 
Unique Identifier:   D064413 

Occurrence in VHL: 		 

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